A total of 445 patients who were diagnosed as HBV-ACLF from January 2005 to February 2014 were included in this research. The minimum follow-up period for enrolled patients was 30-day after diagnosis. The diagnosis of cirrhosis was according to a composite of clinical signs and findings provided through laboratory test results, radiologic imaging, endoscopy and liver biopsy.
The entry criteria comprised the following:HBV-ACLF is defined as ACLF with previously diagnosed or undiagnosed HBV. All enrolled patients met the criteria for ACLF from the consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) [33 (link)]. All treatments were performed based on the criteria of diagnostic and treatment guidelines for ACLF adopted by the Chinese Medical Association [34 (link)].
The exclusion criteria were the following: other factors induce severe liver injury, such as alcohol, drugs, hepatoviruses other than HBV, autoimmunity and pregnancy, as well as genetic and metabolic disorders. HBV-ACLF patients with hepatocellular carcinoma, known decompensated cirrhosis prior to onset of acute hepatic insult, age less than 18 years, jaundice induced by hemolytic jaundice and obstructive jaundice, absence of any chronic liver disease on investigations, and prolonged prothrombin time induced by blood system diseases were also excluded. The flowchart for the selection of HBV-ACLF patients was shown in Figure4 .
Derivation cohort data were screened from Beijing You-an Hospital from January 2005 to January 2013, while validation cohort data was collected from three different medical centers from January 2013 to February 2014. Specifically, 30 cases, 24 cases and 40 cases of HBV-ACLF as validation cohort data were collected from Beijing You-an Hospital, Tianjin Third Central Hospital and the Third Affiliated Hospital of Sun Yat-Sen University, respectively. The derivation cohort was applied to determine the predictors of mortality and thus established a prognostic model.
The entry criteria comprised the following:HBV-ACLF is defined as ACLF with previously diagnosed or undiagnosed HBV. All enrolled patients met the criteria for ACLF from the consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) [33 (link)]. All treatments were performed based on the criteria of diagnostic and treatment guidelines for ACLF adopted by the Chinese Medical Association [34 (link)].
The exclusion criteria were the following: other factors induce severe liver injury, such as alcohol, drugs, hepatoviruses other than HBV, autoimmunity and pregnancy, as well as genetic and metabolic disorders. HBV-ACLF patients with hepatocellular carcinoma, known decompensated cirrhosis prior to onset of acute hepatic insult, age less than 18 years, jaundice induced by hemolytic jaundice and obstructive jaundice, absence of any chronic liver disease on investigations, and prolonged prothrombin time induced by blood system diseases were also excluded. The flowchart for the selection of HBV-ACLF patients was shown in Figure
Derivation cohort data were screened from Beijing You-an Hospital from January 2005 to January 2013, while validation cohort data was collected from three different medical centers from January 2013 to February 2014. Specifically, 30 cases, 24 cases and 40 cases of HBV-ACLF as validation cohort data were collected from Beijing You-an Hospital, Tianjin Third Central Hospital and the Third Affiliated Hospital of Sun Yat-Sen University, respectively. The derivation cohort was applied to determine the predictors of mortality and thus established a prognostic model.
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