Genotyping and Quality Control of UK Biobank

The UK Biobank is a population-based cohort study collected from multiple sites across the United Kingdom. Information on genotyping and quality control has previously been described^{14 (link)}. In brief, study participants were genotyped using two similar arrays (Applied Biosystems UK BiLEVE Axiom Array (807,411 markers) and the UK Biobank Axiom Array (825,927 markers)), which were designed for the UK Biobank study. The initial quality control was performed by the UK Biobank analysis team and designed to accommodate the large-scale dataset of ethnically diverse participants, genotyped in many batches, using two similar arrays^{14 (link)}.

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Tanigawa Y., Li J., Justesen J.M., Horn H., Aguirre M., DeBoever C., Chang C., Narasimhan B., Lage K., Hastie T., Park C.Y., Bejerano G., Ingelsson E, & Rivas M.A. (2019). Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology. Nature Communications, 10, 4064.

Publication 2019

UK BiLEVE Axiom Array

Corresponding Organization :

Other organizations : Stanford University, Massachusetts General Hospital, Harvard University, Grail (United States)

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Variable analysis

independent variables

Genotyping arrays (Applied Biosystems UK BiLEVE Axiom Array and UK Biobank Axiom Array)

dependent variables

Not explicitly mentioned

control variables

Ethnically diverse participants
Genotyping performed in multiple batches
Quality control performed by the UK Biobank analysis team

controls

Not specified
Not specified

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