Topical IMQ-Induced Psoriasis Model

An imiquimod (IMQ)-induced psoriasis-like dermatitis murine model was induced by topical administration of IMQ cream (62.5 mg/day for 7 days) on the right flank skin (1.5 × 1.5 cm area) that had been previously depilated. XPO and DXM were topically applied (daily for 5 days) 4 h after IMQ application. Control mice were treated with Vaseline cream. The used compounds were dissolved in a cream of vegetable origin.

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Filippone A., Casili G., Lanza M., Scuderi S.A., Ardizzone A., Capra A.P., Paterniti I., Campolo M., Cuzzocrea S, & Esposito E. (2023). Evaluation of the Efficacy of Xyloglucan, Pea Protein and Opuntia ficus-indica Extract in a Preclinical Model of Psoriasis. International Journal of Molecular Sciences, 24(4), 3122.

Publication 2023

Dermatitis Imiquimod Mice Psoriasis Skin Topical administration Vaseline Vegetable

Corresponding Organization : University of Messina

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Variable analysis

independent variables

Topical administration of IMQ cream (62.5 mg/day for 7 days) on the right flank skin (1.5 × 1.5 cm area)
Topical application of XPO and DXM (daily for 5 days) 4 h after IMQ application

dependent variables

Psoriasis-like dermatitis in the murine model

control variables

Depilation of the right flank skin prior to treatment
Topical application of Vaseline cream (control)

controls

Positive control: Mice treated with IMQ cream
Negative control: Mice treated with Vaseline cream

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