QiDiTangShen granules, whose patent is currently under review (Patent Accepting No. 201410436459.6) from the State Food and Drug Administration of China, contains seven Chinese herbs, including Astragali Radix (Astragalus membranaceus Fisch., Inner Mongolia Autonomous Region), Rehmanniae radix praeparata (Rehmannia glutinosa Libosch., Henan Province), Euryale Semen (Euryale ferox Salisb., Hunan Province), Sophorae Tonkinensis Radix et Rhizoma(Sophora tonkinensis Gagnep., Zhejiang Province), Hirudo (Whitemania pigra Whitman, Guangdong Province), Rhei Radix et Rhizoma (Rheum palmatum L. Qinghai Province) and Baihuasheshecao (Hedyotis diffusa Willd., Fujian Province). The extract of QDTS was provided by Zhuozhoudongle Pharmaceutical Co., Ltd. (Hebei, China). The doses of QDTS and valsartan (Beijing Novartis Pharmaceutical Co., Ltd., Beijing, China) for mice were 3.37 g/kg/day and 10.29 mg/kg/day, respectively, which were acquired at a ratio with the regular human adult dosage (Gao et al., 2018 (link)).
Acetonitrile, analytical grade methanol, and formic acid (HPLC grade) were purchased from Thermo Scientific (Waltham, MA, United States). Ultra-pure water (18.2 MΩ⋅cm) was from a Milli-Q system (Millipore, Bedford, MA, United States). Polytetrafluoroethylene (PTFE) membranes of 0.45 micron used for processing samples were from ANPEL (Shanghai, China).
Acetonitrile, analytical grade methanol, and formic acid (HPLC grade) were purchased from Thermo Scientific (Waltham, MA, United States). Ultra-pure water (18.2 MΩ⋅cm) was from a Milli-Q system (Millipore, Bedford, MA, United States). Polytetrafluoroethylene (PTFE) membranes of 0.45 micron used for processing samples were from ANPEL (Shanghai, China).
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