Generation and Characterization of Transgenic Mice
The mDia1/miR-146a DKO mice have been described previously (23 (link)). In brief, Mir146a–/– mice in a C57BL/6 background purchased from The Jackson Laboratory (stock 016239) were crossed with mDia1-deficient mice to generate Diap1–/– Mir146a–/– mice (DKO mice) (6 (link)). To generate Diap1–/– Mir146a–/– Il6–/– TKO mice, IL-6–KO mice purchased from The Jackson Laboratory (stock 002650) were crossed with DKO mice. CD45.1 congenic mice were purchased from Charles River Laboratories (B6-LY-5.12/Cr, strain code 564).
Mei Y., Ren K., Liu Y., Ma A., Xia Z., Han X., Li E., Tariq H., Bao H., Xie X., Zou C., Zhang D., Li Z., Dong L., Verma A., Lu X., Abaza Y., Altman J.K., Sukhanova M., Yang J, & Ji P. (2022). Bone marrow–confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia. The Journal of Clinical Investigation, 132(17), e152673.
Corresponding Organization : Northwestern University
Other organizations :
First Affiliated Hospital of Soochow University, Soochow University, Albert Einstein College of Medicine, Montefiore Medical Center
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