Lung CT Scans at TLC and RV

Subjects were positioned supine within a multidector-row CT scanner (GE HD750: GE Healthcare). Full lung scans were acquired during breath holds at coached TLC (inspiratory scan) and coached RV (expiratory scan) on visit 1 and visit 2. The scanning protocol was based on the SPIROMICS study protocol (67 (link)–70 (link)). The scan parameters for the GE HD750 were as follows: 120 kV and current of 180 mA for inspiratory scans and 100 mA for expiratory scans. The slice thickness was 0.625 mm with an interval of 0.5 mm and a pitch of 0.984:1. Spatial resolution was matched at baseline and follow-up using a similar diameter field of view for both scanning sessions. Scans were reconstructed with filtered back projection and standard kernel, and they were deidentified prior to transfer to the University of Iowa for analysis. Three deep breaths to standardize lung volume history preceded scans. Subjects were coached to reach TLC and RV, and the maneuvers were rehearsed prior to scanning.

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Adam R.J., Hisert K.B., Dodd J.D., Grogan B., Launspach J.L., Barnes J.K., Gallagher C.G., Sieren J.P., Gross T.J., Fischer A.J., Cavanaugh J.E., Hoffman E.A., Singh P.K., Welsh M.J., McKone E.F, & Stoltz D.A. (2016). Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalities. JCI Insight, 1(4), e86183.

Publication 2016

GE HD750

Ct scanner Expiratory Inspiratory Lung Lung volume

Corresponding Organization : Institute of Molecular Biology and Biophysics

Other organizations : University of Washington, Cancer Research And Biostatistics, Howard Hughes Medical Institute

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Variable analysis

independent variables

Lung volume levels (total lung capacity (TLC) and residual volume (RV))

dependent variables

Lung scans (inspiratory and expiratory)

control variables

Scan parameters (120 kV and current of 180 mA for inspiratory scans, 100 mA for expiratory scans, slice thickness of 0.625 mm with an interval of 0.5 mm and a pitch of 0.984:1)
Spatial resolution (matched at baseline and follow-up using a similar diameter field of view for both scanning sessions)
Reconstruction method (filtered back projection and standard kernel)
Lung volume history (three deep breaths to standardize prior to scans)
Coaching for lung volume levels (subjects coached to reach TLC and RV, and the maneuvers were rehearsed prior to scanning)

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