Multiparametric MRI Assessment of Health

Participants were scanned at Perspectum Gemini (Oxford: n=338; MAGNETOM Aera 1.5T scanner) and Mayo Clinic (London: n=198; MAGNETOM Vida 3T) (both scanners: Siemens Healthcare, Erlangen, Germany), at baseline and follow-up with multiorgan, multiparametric MRI assessment (total ~40 min duration). All imaging methods were deployed in standard clinical MRI scanners using slightly modified versions of previously published methods11 12 (link) and using short (<14 s) breath-holds except for lung imaging (online supplemental methods 4 and 5).
After each visit, participants and if requested their primary care physicians also, received a clinical summary and a report informing on the MRI data, where quantitative metrics were referenced against the healthy control population, and one on the blood biomarker data.