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Investigating PXR-mediated xenobiotic and lipid metabolism

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Gwag T., Meng Z., Sui Y., Helsley R.N., Park S.H., Wang S., Greenberg R.N, & Zhou C. (2019). Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis. Journal of hepatology, 70(5), 930-940.
Publication 2019
Albumin Alleles Animals Blood Body weight C57bl mice Cholesterol Clones Corn oil Diet Efavirenz Emtricitabine Gavage Hepatocyte Heterozygous Institutional animal care and use committee Knockout mouse Lipid metabolism Low fat diet Male Mice Mouse embryonic stem cell Pathogen Tissue specific Tissues Transgenic mice Xenobiotic

Corresponding Organization : University of Kentucky

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