Micro-CT Analysis of Bone Implant Integration

High-resolution micro-CT images were used to assess new bone formation surrounded the implanted materials. The scanning was performed with X-ray tube set at 70 kVp and 114 µA (µCT80, Scanco Medical, Bassersdorf, Switzerland). Integration time (300 ms) was required for each sample and the region of interest had a resolution of 30 µm. The generated grey scale images were then reconstructed and analysed with the Scanco software. According to our previous work, a global threshold was adopted to differentiate the materials from bony tissue [27–29 (link)]. Three-dimensional (3D) images were extracted from the operated intervertebral lumbar region to visualize the connectivity between the implants and the new bone. Implant circumference and the length of all circumferential segments with direct contact between implant and bone were measured. Circumferential contact index (%) of the PMMA and PMMA-MC groups was calculated in accordance with literature [30 (link)].

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Yang L., Kong J., Qiu Z., Shang T., Chen S., Zhao R., Raucci M.G., Yang X, & Wu Z. (2019). Mineralized collagen-modified PMMA cement enhances bone integration and reduces fibrous encapsulation in the treatment of lumbar degenerative disc disease. Regenerative Biomaterials, 7(2), 181-193.

Publication 2019

µCT80

Bone Bone formation Bony tissue Lumbar region Micro ct Pmma X ray

Corresponding Organization :

Other organizations : Sichuan University, Hebei Medical University, Xingtai People's Hospital, Tsinghua University, Institute of Polymers, Composites and Biomaterials, National Research Council

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Variable analysis

independent variables

Implanted materials

dependent variables

New bone formation surrounded the implanted materials
Implant circumference
Length of all circumferential segments with direct contact between implant and bone
Circumferential contact index (%) of the PMMA and PMMA-MC groups

control variables

X-ray tube set at 70 kVp and 114 µA
Integration time of 300 ms for each sample
Region of interest resolution of 30 µm

controls

No positive or negative controls were explicitly mentioned.

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