Protocol detail

Genetically Modified Mouse Models

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The following mice were purchased from the Jackson Laboratories and/or bred at the University of Alabama at Birmingham (UAB): C57BL/6J (B6), B6.OT-II TCR transgenic mice (OT-II), BALB/cByJ (BALB/c), B6.129S1-Il12b^tm/Jm/J (Il12b^-/- or Il12p40^-/-), 129S2-Stat4^tm1Gru/J (Stat4^-/-) and B6.Il10^-/-. The generation of IL-17F/Thy1.1 knock-in mice was described previously [10 (link)]. All animals were bred and maintained in accordance with UAB Institutional Animal Care and Use Committee (IACUC) regulations.

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Lee Y.K., Landuyt A.E., Lobionda S., Sittipo P., Zhao Q, & Maynard C.L. (2017). TCR-independent functions of Th17 cells mediated by the synergistic actions of cytokines of the IL-12 and IL-1 families. PLoS ONE, 12(10), e0186351.

Publication 2017

C57BL/6J (B6), BALB/cByJ

Animals Il 17f Il10 Institutional animal care and use committee Mice Stat4 Transgenic mice

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Variable analysis

independent variables

C57BL/6J (B6)
B6.OT-II TCR transgenic mice (OT-II)
BALB/cByJ (BALB/c)
B6.129S1-Il12b^tm/Jm/J (Il12b^-/- or Il12p40^-/-)
129S2-Stat4^tm1Gru/J (Stat4^-/-)
B6.Il10^-/-
IL-17F/Thy1.1 knock-in mice

dependent variables

Not explicitly mentioned

control variables

All animals were bred and maintained in accordance with UAB Institutional Animal Care and Use Committee (IACUC) regulations

positive controls

Not specified

negative controls

Not specified

Annotations

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