Estradiol Benzoate Wound Healing Protocol

Estradiol benzoate (OVAHORMON^®INJECTION; ASKA Pharmaceutical Co. Ltd., Tokyo, Japan) was applied to wounds at 0.75 μg/g/day every day following wounding procedures under inhalational anesthesia [21 (link)]. In brief, estradiol benzoate was applied to cover the wound surface after cleaning the wounds with normal saline. Estradiol benzoate was diluted at 0.75 μg/g in sesame oil (Wako Pure Chemical Industries Ltd., Tokyo, Japan). The sesame oil vehicle was applied at the same dose as estradiol benzoate to wounds every day following wounding.

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Mukai K., Nakajima Y., Asano K, & Nakatani T. (2019). Topical estrogen application to wounds promotes delayed cutaneous wound healing in 80-week-old female mice. PLoS ONE, 14(11), e0225880.

Publication 2019

OVAHORMON®INJECTION sesame oil

Anesthesia procedures Estradiol benzoate Inhalational Inhalational anesthesia Normal saline Pharmaceutical Sesame oil

Corresponding Organization : Kanazawa University

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Variable analysis

independent variables

Estradiol benzoate (OVAHORMON® INJECTION; ASKA Pharmaceutical Co. Ltd., Tokyo, Japan) was applied to wounds at 0.75 μg/g/day every day following wounding procedures

dependent variables

Wound healing

control variables

Sesame oil (Wako Pure Chemical Industries Ltd., Tokyo, Japan) was applied at the same dose as estradiol benzoate to wounds every day following wounding

controls

Sesame oil vehicle was used as a negative control

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