The subjects were recruited from the Cardiac Aging Study (CAS), a prospective study initiated in 2014 that examines characteristics and determinants of cardiovascular function in elderly adults14 (link).
The current analysis is a cross-sectional analysis between left atrial function and metabolomics profiling obtained from subjects recruited from the CAS study. Subjects who had self-reported history of physician-diagnosed cardiovascular disease (such as coronary heart disease, atrial fibrillation and stroke) or cancer were excluded. A total of 128 participants were studied in this analysis. The SingHealth Centralised Institutional Review Board had approved the study protocol. Informed consent was obtained from all participants. All methods were performed in accordance with the relevant guidelines and regulations.
All participants were examined and interviewed on one study visit by trained study coordinators. Participants completed a standardized questionnaire that included medical history and coronary risk factors. Hypertension was defined by current use of antihypertensive drugs or physician-diagnosed hypertension. Diabetes mellitus was defined by current use of anti-diabetic agents or physician-diagnosed diabetes mellitus. Dyslipidemia was defined by current use of lipid-lowering agents or physician-diagnosed dyslipidemia. Smoking history was defined as ever smokers (former or current smoking) or never smokers. Body mass index was calculated as weight in kilograms divided by the square of height in meters. Sinus rhythm status was ascertained by resting electrocardiogram. Clinical data were obtained on the same day as assessment of cardiac magnetic resonance (CMR) imaging and serum collection.
The current analysis is a cross-sectional analysis between left atrial function and metabolomics profiling obtained from subjects recruited from the CAS study. Subjects who had self-reported history of physician-diagnosed cardiovascular disease (such as coronary heart disease, atrial fibrillation and stroke) or cancer were excluded. A total of 128 participants were studied in this analysis. The SingHealth Centralised Institutional Review Board had approved the study protocol. Informed consent was obtained from all participants. All methods were performed in accordance with the relevant guidelines and regulations.
All participants were examined and interviewed on one study visit by trained study coordinators. Participants completed a standardized questionnaire that included medical history and coronary risk factors. Hypertension was defined by current use of antihypertensive drugs or physician-diagnosed hypertension. Diabetes mellitus was defined by current use of anti-diabetic agents or physician-diagnosed diabetes mellitus. Dyslipidemia was defined by current use of lipid-lowering agents or physician-diagnosed dyslipidemia. Smoking history was defined as ever smokers (former or current smoking) or never smokers. Body mass index was calculated as weight in kilograms divided by the square of height in meters. Sinus rhythm status was ascertained by resting electrocardiogram. Clinical data were obtained on the same day as assessment of cardiac magnetic resonance (CMR) imaging and serum collection.
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