The primary data were the level of LDL-C, TC and HDL-C concentrations at the end point and are expressed as mean and standard deviation (SD). Additional data obtained from the studies included publication year, the first author, age, number of male and total participants, p value, follow-up time and the dose of ezetimibe and statin. To ascertain the validity of eligible randomized trials, pairs of reviewers working independently and determined the adequacy of randomization and concealment of allocation, data collectors, and outcome assessors. The effect size between treatment groups within individual studies was assessed by weighted mean difference (MD). Disagreements were resolved by consensus between the two readers and studies included were all randomized double-blind controlled study.
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