Each participant underwent a standardized neuropsychological assessment battery. Global cognitive screening was performed using the MMSE, and disease severity was assessed using the CDR® and the 6 domains of CDR® plus the behaviour/comportment and language domains (CDR® plus NACC FTLD). The severity of behavioural abnormalities was assessed using the Frontal Behaviour Inventory (FBI), which can be separated into the negative apathy symptom subscale (first 12 items) and the positive disinhibition symptom subscale (last 12 items). Executive function was evaluated using the Trail Making Test (TMT) and the Stroop I and II tests. Language deficits were tested using the 30-item Boston Naming Test (BNT). Activities of living were assessed by the following scales: activities of daily living (ADL).
Controls in our plasma cohort did not complete the FBI, TMT, BNT and ADL scales. To clearly show how affected the patients truly are, we calculated the z scores by selecting another group of controls who were age- and sex-matched with bvFTD patients and completed the FBI, TMT, BNT and ADL scales.
Controls in our plasma cohort did not complete the FBI, TMT, BNT and ADL scales. To clearly show how affected the patients truly are, we calculated the z scores by selecting another group of controls who were age- and sex-matched with bvFTD patients and completed the FBI, TMT, BNT and ADL scales.
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