Poly-DL-alanine, acetaminophen, betaine hydrochloride, and drug standards were purchased from Sigma-Aldrich (St. Louis, MO). Drug CCS calibrants were obtained as descried previously.20 (link) Human liver microsomes (HLM) and S9-fraction (S9) pooled from 100 male and 100 female individuals were purchased from Sekisui XenoTech (Kansas City, KS). C12, C14, and C16 benzalkonium chlorides (BACs) and the synthetic precursors necessary for synthesizing additional BACs and ω-hydroxy BAC analogs were purchased from Sigma-Aldrich (St. Louis, MO). Synthesis of BACs and their ω-OH analogs is detailed in the Supporting Information .
Protocol detail
Analysis of Benzalkonium Chlorides and Analogs
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Acetaminophen
Benzalkonium chlorides
Betaine hydrochloride
Drug
Female
Human
Liver microsomes
Male
Poly dl alanine
Synthesis
Corresponding Organization : University of Washington
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Variable analysis
independent variables
- Poly-DL-alanine
- Acetaminophen
- Betaine hydrochloride
- Drug standards
- Drug CCS calibrants
- Human liver microsomes (HLM)
- S9-fraction (S9)
- C12, C14, and C16 benzalkonium chlorides (BACs)
- Synthetic precursors necessary for synthesizing additional BACs and ω-hydroxy BAC analogs
- Not explicitly mentioned
- Not explicitly mentioned
- Not explicitly mentioned
- Not explicitly mentioned
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