For protein isolation and western blotting, cells were washed with 1X PBS and lysed in radio-immunoprecipitation assay (RIPA) lysis buffer (25 mM Tris-HCl pH 7.6, 150 mM NaCl, 1% NP-40, 1% sodium Deoxycholate, 0.1% SDS supplemented with protease inhibitor tablets). Protein quantification and western blotting were carried out as previously described (36 (link)). Antibody against MUC1 has been previously described (51 (link)). Antibodies against GRP78, CHOP, NRF2 and O-GlcNAc were from Cell Signaling Technology. CDA antibody was from Santa Cruz Technology (Dallas, TX USA).