Spironolactone (SPL) was obtained from Sigma-Aldrich, St. Louis, MO, USA. Poly(lactic-co-glycolic acid) (PLGA) (lactide–glycolide 50:50 (ester terminated) and 75:25 (acid terminated), Viscosity 1 and 0.2 dL/g, respectively) was kindly supplied by Purac Biomaterials, Holland. Polyvinyl alcohol (87.0–89.0% hydrolyzed, molecular weight 31,000–50,000 Da) was obtained from Acros Organics, Belgium. Acetone, methylene chloride, dimethylsulfoxide (DMSO), and methanol were bought from Adwic, EL Nasr Pharmaceutical Chemicals, Co., Egypt. All other materials were of fine analytical grades. Praziquantel (PZQ) was supplied from Alexandria Company for Pharmaceuticals & Chemical Industries, Egypt.
Protocol detail
Spironolactone-loaded PLGA nanoparticles
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Acetone
Acid
Biomaterials
Dimethylsulfoxide
Ester
Glycolic acid
Lactide
Methanol
Methylene chloride
Pharmaceuticals
Plga
Poly
Polyvinyl alcohol
Praziquantel
Spironolactone
Viscosity
Corresponding Organization :
Other organizations : Mansoura University
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Variable analysis
independent variables
- Spironolactone (SPL)
- Poly(lactic-co-glycolic acid) (PLGA) (lactide–glycolide 50:50 (ester terminated) and 75:25 (acid terminated), Viscosity 1 and 0.2 dL/g, respectively)
- Polyvinyl alcohol (87.0–89.0% hydrolyzed, molecular weight 31,000–50,000 Da)
- Praziquantel (PZQ)
- Measured outcomes not explicitly mentioned
- Acetone
- Methylene chloride
- Dimethylsulfoxide (DMSO)
- Methanol
- All other materials were of fine analytical grades
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