Investigating Inflammatory Causes of OCD

Blood analyses were offered to all patients as a routine procedure upon admission. The methodology of the tests has been described in previous publications [23 (link), 25 (link)–27 (link)]. In addition to these routine diagnostic tests, 15 selected patients with suspected autoimmune OCD [16 (link), 28 ] received a lumbar puncture to investigate an inflammatory cause of OCD. The CSF findings of OCD patients from our hospital were recently summarized in another publication, including patients from other wards and a larger retrospective interval [25 (link), 28 ]. To discover potential novel anti-CNS antibodies, CSF–serum pairs of 12 patients were investigated on slices of unfixed murine brain tissue by indirect immunofluorescence [29 (link), 30 (link)].

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Runge K., Reisert M., Feige B., Nickel K., Urbach H., Venhoff N., Tzschach A., Schiele M.A., Hannibal L., Prüss H., Domschke K., Tebartz van Elst L, & Endres D. (2023). Deep clinical phenotyping of patients with obsessive-compulsive disorder: an approach towards detection of organic causes and first results. Translational Psychiatry, 13, 83.

Publication 2023

Anti antibodies Blood analyses Brain Indirect immunofluorescence Inflammatory Lumbar puncture Murine Patients Routine diagnostic tests Serum Tissue

Corresponding Organization :

Other organizations : University of Freiburg, University Medical Center Freiburg, Charité - Universitätsmedizin Berlin

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Variable analysis

independent variables

Suspected autoimmune OCD in 15 selected patients

dependent variables

Inflammatory causes of OCD
Potential novel anti-CNS antibodies

control variables

Blood analyses were offered to all patients as a routine procedure upon admission
The methodology of the blood tests has been described in previous publications

controls

Positive controls: Not specified
Negative controls: Not specified

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