Magnetic Resonance Imaging in Piglet Neurodevelopment

At 30 days of age, piglets underwent magnetic resonance imaging (MRI) procedures. Piglets were scanned on a Siemens MAGNETOM Trio 3T Imager using a Siemens 32-channel head coil. Upon arrival to the Beckman Institute Biomedical Imaging Center, piglets were anesthetized via intramuscular injection of Telazol (0.07 mg/kg body weight; Zoetis, Florham Park, NJ, USA). Once sedated, piglets were transferred to the MRI scanner and maintained on 2% isoflurane/98% oxygen for the entirety of the 60 min scan. An MRI-compatible pulse oximeter was used to monitor piglet vital signs throughout the scan. Upon completion of the scan, vital signs were monitored and recorded until complete recovery from anesthesia. Specific details regarding piglet imaging sequences and post-imaging analysis of diffusion tensor imaging (DTI) and voxel-based morphometry were previously described (18 (link), 20 (link)).

Free full text: Click here

Mudd A.T., Alexander L.S., Berding K., Waworuntu R.V., Berg B.M., Donovan S.M, & Dilger R.N. (2016). Dietary Prebiotics, Milk Fat Globule Membrane, and Lactoferrin Affects Structural Neurodevelopment in the Young Piglet. Frontiers in Pediatrics, 4, 4.

Publication 2016

MAGNETOM Trio 3T Imager 32-channel head coil Telazol

Anesthesia Body weight Head Intramuscular injection Isoflurane Oxygen Pulse Scan Telazol Trio Vital signs

Corresponding Organization :

Other organizations : University of Illinois Urbana-Champaign, Mead Johnson (United States)

Top 5 similar protocols

Protocol cited in 2 other protocols

Variable analysis

independent variables

Age of piglets (30 days)

dependent variables

Brain structure and function measured by MRI (diffusion tensor imaging (DTI) and voxel-based morphometry)

control variables

Anesthesia administration (Telazol, 0.07 mg/kg body weight; isoflurane/oxygen)
Monitoring of vital signs during scan (pulse oximeter)
Recovery monitoring after scan

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!