Untargeted Metabolomic Profiling of EPIC-Norfolk

Genotyping, imputation and untargeted metabolite profiling of baseline non-fasted serum samples from 9,712 unrelated European individuals in the EPIC-Norfolk cohort was performed using the Discovery HD4 platform (Metabolon, Inc.), as previously described^{32 (link),34 (link)}.

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Lam B.Y., Williamson A., Finer S., Day F.R., Tadross J.A., Soares A.G., Wade K., Sweeney P., Bedenbaugh M.N., Porter D.T., Melvin A., Ellacott K.L., Lippert R.N., Buller S., Rosmaninho-Salgado J., Dowsett G.K., Ridley K.E., Xu Z., Cimino I., Rimmington D., Rainbow K., Duckett K., Holmqvist S., Khan A., Dai X., Bochukova E.G., Trembath R.C., Martin H.C., Coll A.P., Rowitch D.H., Wareham N.J., van Heel D.A., Timpson N., Simerly R.B., Ong K.K., Cone R.D., Langenberg C., Perry J.R., Yeo G.S, & O’Rahilly S. (2021). MC3R links nutritional state to childhood growth and the timing of puberty. Nature, 599(7885), 436-441.

Publication 2021

Discovery HD4

European Serum

Corresponding Organization :

Other organizations : Wellcome/MRC Institute of Metabolic Science, University of Cambridge, Queen Mary University of London, MRC Epidemiology Unit, University of Bristol, University of Michigan–Ann Arbor, Vanderbilt University, University of Exeter, German Institute of Human Nutrition, Hospitais da Universidade de Coimbra, King's College London, Wellcome Sanger Institute

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Variable analysis

independent variables

Genotyping
Imputation
Untargeted metabolite profiling

dependent variables

Metabolite levels in non-fasted serum samples

control variables

Baseline non-fasted serum samples
9,712 unrelated European individuals in the EPIC-Norfolk cohort

controls

Positive controls not explicitly mentioned
Negative controls not explicitly mentioned

Annotations

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