Rat Open Field Exploration Behavior

This test was performed as described previously [20 (link)]. The open field consisted of a square arena (100 × 100 cm) with 25 squares on the ground and a 20 cm wall around it. A camera was attached to a computer above the arena. The rats were individually placed in the center of the arena and allowed free exploration for 5 min. The rat behaviors in the arena were recorded by Observer 5.0 software (Noldus, Wageningen, Netherlands) and analyzed by EthoVision 14.0 software (Noldus, Netherlands), including the total distance moved and time spent in the central area.

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Qiu W., Wu Q., Zhang K., Da X., Tang K., Yuan N., Deng L., Wu M., Zhang Y., Quan J., Ma Q., Li X, & Chen J. (2023). Xiaoyaosan ameliorates depressive-like behavior and susceptibility to glucose intolerance in rat: involvement of LepR-STAT3/PI3K pathway in hypothalamic arcuate nucleus. BMC Complementary Medicine and Therapies, 23, 116.

Publication 2023

Observer 5.0 software EthoVision 14.0 software

Corresponding Organization :

Other organizations : Beijing University of Chinese Medicine, Jinan University

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Total distance moved
Time spent in the central area

control variables

Size of the arena (100 × 100 cm)
Number of squares on the ground (25)
Height of the wall around the arena (20 cm)
Placement of the rat (individually in the center of the arena)
Duration of the test (5 min)
Recording software (Observer 5.0)
Analysis software (EthoVision 14.0)

controls

None explicitly mentioned

Annotations

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