FTIR Analysis of Fabricated Nanocubosomes

The presence of representative functional groups and intramolecular interactions amid the drugs and GMO in fabricated nanocubosomes were analyzed by FTIR spectroscopy (Bruker, Karlsruhe, Germany) (Iqbal et al., 2021 ; Khan et al., 2022 (link)). Briefly, a small quantity of Cur, TMZ, CTNCs and blank nanocubosomes freeze-dried powder were directly placed on sample chamber and IR spectrum was measured in the IR range (500–4000 cm⁻¹), with 2 mm sec⁻¹ scanning speed for 120 scans with 4 cm⁻¹ resolution.

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Almoshari Y., Iqbal H., Razzaq A., Ali Ahmad K., Khan M.K., Saeed Alqahtani S., Hadi Sultan M, & Ali Khan B. (2022). Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective Colon cancer therapy. Drug Delivery, 29(1), 2633-2643.

Publication 2022

FTIR spectroscopy

Drugs interactions Freeze Ftir spectroscopy Powder

Corresponding Organization :

Other organizations : Jazan University, Cancer Hospital of Chinese Academy of Medical Sciences, University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Soochow University, Gomal University

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Variable analysis

independent variables

Cur (Curcumin)
TMZ (Temozolomide)
CTNCs (Curcumin and Temozolomide Loaded Nanocubosomes)
Blank nanocubosomes

dependent variables

Presence of representative functional groups
Intramolecular interactions

control variables

IR range (500–4000 cm^-1)
Scanning speed (2 mm sec^-1)
Number of scans (120)
Resolution (4 cm^-1)

controls

Blank nanocubosomes (as a control)

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