Lipid/Heparin Infusion and Insulin Resistance

Participants underwent saline-control or lipid/heparin infusions (Liposyn II or Intralipid; 20% lipid emulsion at 45 cc/hour, heparin at 0.4 U/kg/min), in the presence or absence of a HEC, conducted at 4 separate visits, for 6 hours commencing at approximately 6AM. The study was initiated with Liposyn II (Abbott Laboratories, North Chicago, IL; 10% safflower oil, 10% soybean oil, 1.2% egg phosphatides and 2.5% glycerin; major component fatty acids: approximately 65.8% linoleic, 17.7% oleic, 8.8% palmitic, 3.4% stearic, and 4.2% linolenic acid), but due to a product recall, some participants received Intralipid (Baxter Healthcare Corporation, Deerfield, IL; 20% Soybean oil, 1.2%egg yolk phospholipids, 2.25% glycerin; major component fatty acids: linoleic (44-62%), oleic (19-30%), palmitic (7-14%), linolenic (4-11%) and stearic (1.4-5.5%) instead. Liposyn and Intralipid are reported to induce similar degrees of insulin resistance (20 (link), 21 (link)) and this was confirmed within this study (see results).

Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link: Access Free Full Text.

Chosich J., Bradford A.P., Allshouse A.A., Reusch J.E., Santoro N, & Schauer I.E. (2017). Acute Recapitulation of the Hyperinsulinemia and Hyperlipidemia characteristic of Metabolic Syndrome suppresses Gonadotropins. Obesity (Silver Spring, Md.), 25(3), 553-560.

Publication 2016

Liposyn II Intralipid

Egg yolk Emulsion Fatty acids Glycerin Heparin Insulin resistance Intralipid Linolenic acid Lipid Liposyn Liposyn ii Phospholipids Safflower oil Saline Soybean oil

Corresponding Organization : University of Colorado Denver

Other organizations : Colorado School of Public Health

Top 5 similar protocols

Variable analysis

independent variables

Saline-control infusion
Lipid/heparin infusion (Liposyn II or Intralipid)

dependent variables

Insulin resistance

control variables

Infusion duration (6 hours)
Infusion start time (approximately 6AM)
Heparin infusion rate (0.4 U/kg/min)
Lipid infusion rate (45 cc/hour)

positive controls

Liposyn II (10% safflower oil, 10% soybean oil, 1.2% egg phosphatides and 2.5% glycerin)

negative controls

Saline-control infusion

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!