Magnetic resonance examinations were performed on a 1.5 T magnetom (Siemens Healthcare, Erlangen, Germany) and a 3 T magnetom (Philips Health, Hong Kong, China). Tumor regions included viable tumors, peritumoral edema, and equivalent midline normal tissue (EMNT). The description of MRI evaluation was previously described in our publication in 2023 [12 (link)]. The images were not modified during preprocessing; however, they went through a selection process which included the mentioned sequences and slices where the region of interest (ROI) was visible. The images were then uploaded directly to the software LIFEx v.7.1.0 for post-processing [17 (link)].
We included 82 radiomic features in our calculation. In each of the selected brain magnetic resonance images, three regions were chosen to extract the radiomics: viable tumor (represented for enhancing tumor regions in T1 post-gadolinium sequence), peritumoral edema (visualized on T2), and equivalent midline normal tissue (EMNT) observed in both sequences. Two expert neuro-oncologists drew ROIs manually across all slices of the selected sequences individually (T1 post-gadolinium and T2), where the three tumor regions were present.Figure 3 shows an example of the MRI appearance of DMG.
We included 82 radiomic features in our calculation. In each of the selected brain magnetic resonance images, three regions were chosen to extract the radiomics: viable tumor (represented for enhancing tumor regions in T1 post-gadolinium sequence), peritumoral edema (visualized on T2), and equivalent midline normal tissue (EMNT) observed in both sequences. Two expert neuro-oncologists drew ROIs manually across all slices of the selected sequences individually (T1 post-gadolinium and T2), where the three tumor regions were present.
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