Operant Conditioning for Drug Reinforcement

Animals were tested in plexiglass operant chambers (Med Associates, St Albans, VT, USA), equipped with two levers The required number of responses at the reinforced (Reinf) lever turned on a cue light over the lever, turned off the house light, and activated an externally mounted syringe pump that infused drug. During the infusion (5.6 s yielding 100 μL of solution) and timeout period (20 s) the cue light remained illuminated, and the house light remained off. After the timeout period, the house light turned on and signaled the availability of a reinforcer. Responses on the non-reinforced (NonReinf) lever were recorded but had no consequences [28 (link),62 (link)].

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Carreño D., Facundo A., Nguyen M.T, & Lotfipour S. (2024). Dopamine and Norepinephrine Tissue Levels in the Developing Limbic Brain Are Impacted by the Human CHRNA6 3′-UTR Single-Nucleotide Polymorphism (rs2304297) in Rats. International Journal of Molecular Sciences, 25(7), 3676.

Publication 2024

plexiglass operant chambers

Corresponding Organization : University of California, Irvine

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Variable analysis

independent variables

Number of responses at the reinforced (Reinf) lever

dependent variables

Activation of the syringe pump that infused drug
Responses on the non-reinforced (NonReinf) lever

control variables

Plexiglass operant chambers (Med Associates, St Albans, VT, USA)
Two levers
Cue light over the reinforced lever
House light
Syringe pump infusion duration (5.6 s yielding 100 μL of solution)
Timeout period (20 s)

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