Assessing Bone Metabolism in AI Therapy

BMD was measured in the left hip and lumbar spine at baseline and 24 months after AI treatment initiation using dual-energy x-ray absorptiometry (DXA) and converted to T-scores as described previously [7 (link)]. Fasting blood and urine specimens were collected at baseline and after three months of AI treatment for measurement of biochemical BTMs including serum bone-specific alkaline phosphatase (BAP) and urinary type I cross-linked N telopeptides (NTx). BAP and NTx were analyzed using enzyme-linked immunoassay (ELISA) kits (Quidel® Corporation, San Diego, CA) as previously described [7 (link)]. NTX concentrations were corrected for urine dilution by adjusting for the corresponding urine creatinine concentrations.

Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link: Access Free Full Text.

Kamdem L.K., Xi J., Clark B.L., Gregory B.J., Kidwell K.M., Storniolo A.M., Stearns V., Hayes D.F., Gersch C.L., Rae J.M., Henry N.L, & Hertz D.L. (2019). Exemestane may be less detrimental than letrozole to bone health in women homozygous for the UGT2B17*2 gene deletion. Breast cancer research and treatment, 175(2), 297-303.

Publication 2019

ELISA) kits

Alkaline phosphatase Blood Bone Creatinine Dilution Enzyme immunoassay Lumbar spine Serum Urine

Corresponding Organization : Harding University Main Campus

Other organizations : University of Michigan–Ann Arbor, Indiana University Health, Indiana University – Purdue University Indianapolis, Sidney Kimmel Comprehensive Cancer Center, Huntsman Cancer Institute

Top 5 similar protocols

Variable analysis

independent variables

AI treatment initiation

dependent variables

BMD measured in the left hip and lumbar spine
Serum bone-specific alkaline phosphatase (BAP)
Urinary type I cross-linked N telopeptides (NTx)

control variables

Baseline measurements of BMD, BAP, and NTx

controls

Positive control: Not specified
Negative control: Not specified

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!