Participants were enrolled in the MRI substudy between 2003 and 2008. Brain images were obtained with a 1.5T MRI (Philips Medical Systems, Best, the Netherlands). Quantitative analyses of WMH volume (VMHV) were obtained with the Quantum 6.2 package run on a Sun Microsystems Ultra 5 workstation.1 (link) FLAIR images were quantified for WMHV as previously described.23 (link),24 (link) Briefly, after image segmentation of the brain from the cerebral spinal fluid (CSF) was performed, the pixel intensity histogram of the brain-only FLAIR image was modeled as a log normal distribution, and pixel intensities three and one-half standard deviations above the mean were considered as WMH.25 (link) To correct for head size, we expressed WMHV as percent total intracranial volume (ICV), ICV [WMHV=(WMH/ICV)*100] and log-transformed this measure (log-WMHV) to normalize the distribution.26 (link)
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Quantification of White Matter Hyperintensities
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Other organizations : University of Miami, University of Rome Tor Vergata, Columbia University, San Raffaele University of Rome, University of Kansas Medical Center, University Medical Center, University Hospital and Clinics, National Institute of Neurological Disorders and Stroke
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Variable analysis
independent variables
- None explicitly mentioned
- White matter hyperintensity volume (WMHV)
- Participants were enrolled in the MRI substudy between 2003 and 2008
- Brain images were obtained with a 1.5T MRI (Philips Medical Systems, Best, the Netherlands)
- Quantitative analyses of WMH volume (VMHV) were obtained with the Quantum 6.2 package run on a Sun Microsystems Ultra 5 workstation
- FLAIR images were quantified for WMHV as previously described
- After image segmentation of the brain from the cerebral spinal fluid (CSF) was performed, the pixel intensity histogram of the brain-only FLAIR image was modeled as a log normal distribution, and pixel intensities three and one-half standard deviations above the mean were considered as WMH
- To correct for head size, WMHV was expressed as percent total intracranial volume (ICV), and log-transformed to normalize the distribution
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