All animal studies
were conducted under a protocol approved by the University of California,
Davis, Animal Care and Use Committee. 64CuCl2 was purchased from Washington University (St Louis, MO). The details
of the synthesis of radiolabeled micelles and PET imaging scans are
described in previous work.18 (link) In brief,
the pharmacokinetics and in vivo biodistribution
of C16- and C18-micelles were studied by positron emission tomography
(PET) and an automatic gamma counter (PerkinElmer, CT), respectively,
after intravenous administration of the micellar solution to female
FVB mice (n = 6 for C18-micelles, (371 ± 107
μCi and 0.68 ± 0.15 mg per mouse) and n = 4 for C16-micelles, (407 ± 9 μCi and 0.69 ± 0.008
mg/mouse) bearing new deletion mutant (NDL)35 (link),36 (link) tumors implanted bilaterally within the mammary fat pads. All PET
images and the organ distribution of 64Cu-labeled micelles
presented here have been decay corrected.
were conducted under a protocol approved by the University of California,
Davis, Animal Care and Use Committee. 64CuCl2 was purchased from Washington University (St Louis, MO). The details
of the synthesis of radiolabeled micelles and PET imaging scans are
described in previous work.18 (link) In brief,
the pharmacokinetics and in vivo biodistribution
of C16- and C18-micelles were studied by positron emission tomography
(PET) and an automatic gamma counter (PerkinElmer, CT), respectively,
after intravenous administration of the micellar solution to female
FVB mice (n = 6 for C18-micelles, (371 ± 107
μCi and 0.68 ± 0.15 mg per mouse) and n = 4 for C16-micelles, (407 ± 9 μCi and 0.69 ± 0.008
mg/mouse) bearing new deletion mutant (NDL)35 (link),36 (link) tumors implanted bilaterally within the mammary fat pads. All PET
images and the organ distribution of 64Cu-labeled micelles
presented here have been decay corrected.
