Clarithromycin was obtained as a gift sample from the JOSWE Pharmaceutical Company (Amman, Jordan). Phosphoric acid was purchased from RomiL™ (Cambridge, UK), while HPLC-grade acetonitrile and HPLC-grade methanol were purchased from Tedia™ (Fairfield, OH, USA). Span™ 40, Span™ 60, Span™ 80, Tween™ 60, Tween™ 80, and cholesterol (Chol) were purchased from Sigma Aldrich™ (Gillingham, Dorset, UK). Diethyl ether and methanol were purchased from Tedia™ (Fairfield, OH, USA). Cellulose dialysis membranes with a molecular weight cut-off (MWCO) of 12–14 kDa, average flat width of 28.46 mm, and average diameter of 17.5 mm were purchased from HiMedia Laboratories™ (Mumbai, Maharashtra, India). Polyethylene glycol 400 (PEG 400) was purchased from GCC Diagnostics™ (Deeside, Flintshire, UK). Hydroxypropyl methyl cellulose (HPMC) 40,000, dicetyl phosphate (DCP), and phosphate-buffered saline (PBS) tablets were purchased from Sigma Aldrich™ (Gillingham, Dorset, UK). All other chemicals used in this study were of analytical grade.
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