Multimodal Neuroimaging Data Processing

97/101 subjects underwent structural T1-weighted MRI. Scans were obtained on different MRI units, including three 1.5T units (Magnetom Avanto System, Siemens Medical Systems, Erlangen Germany; Magneton VISION system, Siemens Inc., Iselin, NJ; or GE sygna), two 3T units (Siemens Tim Trio/Prisma scanners), and one 4T unit (BrukerMedSpec) at the UCSF neuroimaging center or the UC Davis Imaging Research Center. Acquisition parameters for all scanners have been previously described.^{24 (link),28 (link)} MRI was used for PET image preprocessing only. PET frames were realigned, averaged and co-registered onto their corresponding T1 MRI. T1 MRI images were parcellated using FreeSurfer 5.3 (wsurfer.nmr.mgh.harvard.edu). We calculated PIB standard uptake value ratio (SUVR) using the cerebellar gray matter (defined on the MRI) as the reference region. When 90-minute acquisition was available, we also generated PIB Distribution Volume Ratio (DVR) images using Logan graphical analysis with cerebellar gray matter as the reference region. FDG SUVR images were created using the pons (defined on the MRI) as a reference region.^{29 –31 (link)}

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Lesman-Segev O.H., Joie R.L., Iaccarino L., Lobach I., Rosen H.J., Seo S.W., Janabi M., Baker S.L., Edwards L., Pham J., Olichney J., Boxer A., Huang E., Gorno-Tempini M., DeCarli C., Hepker M., Hwang J.H., Miller B.L., Spina S., Grinberg L.T., Seeley W.W., Jagust W.J, & Rabinovici G.D. (2020). Diagnostic Accuracy of Amyloid versus FDG PET in Autopsy-Confirmed Dementia. Annals of neurology, 89(2), 389-401.

Publication 2020

Magnetom Avanto System Magneton VISION system

Cerebellar gray matter Frames Pons Prisma Scans Trio

Corresponding Organization : University of California, Berkeley

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Protocol cited in 2 other protocols

Variable analysis

independent variables

Independent variables not explicitly mentioned.

dependent variables

PIB standard uptake value ratio (SUVR) using the cerebellar gray matter as the reference region
PIB Distribution Volume Ratio (DVR) images using Logan graphical analysis with cerebellar gray matter as the reference region
FDG SUVR images using the pons as a reference region

control variables

Structural T1-weighted MRI scans obtained on different MRI units, including three 1.5T units, two 3T units, and one 4T unit
Acquisition parameters for all scanners have been previously described

positive controls

None specified

negative controls

None specified

Annotations

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