ADCP and ADNP experiments were performed as previously described 18 (link),19 (link). Briefly, antigen proteins of the target were biotinylated using the EZ-link™Sulfo-NHS-LC-LC-Biotin kit (Thermo Fisher), then coupled to the fluorescent neutravidin beads (Thermo Fisher, F8776). The bead-antigen conjugates were incubated with diluted serum and BAL samples (serum: 1:100, BAL: 1:10) for 2 h at 37°C. The unbound antibody was removed by washing buffer. The immune complexes were then incubated overnight with cultured THP-1 cells (ADCP), or for 1 h with primary neutrophils isolated from human whole blood (ADNP) using negative selection (Stemcell). Treated THP-1 cells were subsequently washed and fixed in 4% paraformaldehyde (PFA), while the treated neutrophils were washed, stained for CD66b+ marker (Biolegend), and fixed in 4% (PFA) prior to flow cytometry analysis. A phagocytosis score for THP-1 or neutrophil was eventually determined as (% cells positive × Median Fluorescent Intensity of positive cells). Flow cytometry was performed with an iQue (IntelliCyt) instrument and population measurements were conducted using IntelliCyt ForeCyt (v8.1). The reagents and materials used are listed in the Key Resources Tables.