Treatment duration was 7-14 days. After 3 days (9 doses) of IV therapy, optional open-label, standard-of-care, oral step-down therapy was permitted at the investigator’s discretion, with choice of therapy guided by culture and antibacterial susceptibility results, as well as local standard of care for treatment of cUTI. Recommended options for oral step-down therapy were β-lactam/β-lactamase inhibitor combinations, cephalosporins, fluoroquinolones, nitrofurantoin, trimethoprim‚ or trimethoprim/sulfamethoxazole.
Pediatric Ceftolozane/Tazobactam vs Meropenem for cUTI
Treatment duration was 7-14 days. After 3 days (9 doses) of IV therapy, optional open-label, standard-of-care, oral step-down therapy was permitted at the investigator’s discretion, with choice of therapy guided by culture and antibacterial susceptibility results, as well as local standard of care for treatment of cUTI. Recommended options for oral step-down therapy were β-lactam/β-lactamase inhibitor combinations, cephalosporins, fluoroquinolones, nitrofurantoin, trimethoprim‚ or trimethoprim/sulfamethoxazole.
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Corresponding Organization : Hippocration General Hospital
Other organizations : Children's Hospital of Orange County, Rady Children's Hospital-San Diego, University of California, San Diego, MSD (United States)
Variable analysis
- Dose of ceftolozane/tazobactam
- Dose of meropenem
- Treatment duration (7-14 days)
- Optional open-label, standard-of-care, oral step-down therapy
- Infusion duration (60 minutes ± 10 minutes)
- Dosing frequency (every 8 hours ± 1 hour)
- Positive control: meropenem
- Negative control: not specified
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