FDG-PET scans were acquired in 47 PD patients and 11 controls after overnight fasting in the OFF-state since it has been shown that the ON-state could alter neural functions in PD (Tahmasian et al., 2015 (link), 2017 (link)). Images were recorded on a Siemens high-resolution research tomograph (ECAT HRRT) with 207 transaxial image planes and a voxel size of 1.219 mm (isotropic) in 3D acquisition mode. Subjects lay comfortably in a supine position in a quiet room with dimmed light; a vacuum cushion was used to restrict head motion. Following a transmission scan for attenuation correction, 185 MBq 2-[fluorine-18]fluoro-2-deoxy-d -glucose were injected. Recording started 20 s after injection and continued for 60 min, with one frame saved every 10 min. Using software VINCI (Vollmar et al., 2003 ), frames were co-registered together; an average of frames 3–6 (minute 20–60) was generated and saved in the Nifti format for the following analysis.
High-resolution T1-weighted MRI scans, acquired on a 3T Siemens Magnetom Prisma with a voxel size of 0.9 × 0.9 × 0.9 mm3, were available for 43 of the 47 patients and the 11 controls who underwent FDG-PET. In PD patients, MRI scans were performed under regular dopaminergic medication to reduce head motion (Tahmasian et al., 2015 (link)).
High-resolution T1-weighted MRI scans, acquired on a 3T Siemens Magnetom Prisma with a voxel size of 0.9 × 0.9 × 0.9 mm3, were available for 43 of the 47 patients and the 11 controls who underwent FDG-PET. In PD patients, MRI scans were performed under regular dopaminergic medication to reduce head motion (Tahmasian et al., 2015 (link)).
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