Bromocriptine Effects on Obese GK Rats

The experimental design for bromocriptine administration was similar to sleeve gastrectomy, namely the WSD and GKSD groups (Figure 5A). A group of GK rats (GKHCD; n = 18) was fed the same high-caloric diet between 1 and 6-months-old. At 5 months old, the HCD-fed group was randomly divided into three groups (n = 6): the first without further treatment (GKHCD); HCD rats treated with bromocriptine in the last month (GKHCD_Br), and HCD rats treated with a vehicle DMSO solution during the same period (GKHCD_Vh) [12 (link)]. Bromocriptine, gently supplied by Generis^®, (Amadora, Portugal) was diluted 1:4 DMSO/H2O and administered daily by intraperitoneal (i.p.) injection (10 mg/Kg/day) during the last month. In the vehicle group, the same volume (100 μL) of the vehicle 1:4 DMSO/H2O was administered i.p. during the same period.