All the animal procedures were approved by the Ohio State University Institutional Animal Care and Use Committee and conformed to the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH publication N. 85-23, revised 1996).
Archived data from 74 heartworm free mixed breed dogs (1–3 y old, male n = 32, female n = 42) weighing 19.3 ± 0.4 kg (range = 11.6–26.8 kg) were used in the present study. The sole selection criterion was an ECG signal of sufficient quality to determine HRV both at baseline and in response to autonomic neural interventions (i.e., submaximal exercise, baroreceptor reflex activation, pharmacological autonomic blockade, or bilateral cervical vagotomy).
Archived data from 74 heartworm free mixed breed dogs (1–3 y old, male n = 32, female n = 42) weighing 19.3 ± 0.4 kg (range = 11.6–26.8 kg) were used in the present study. The sole selection criterion was an ECG signal of sufficient quality to determine HRV both at baseline and in response to autonomic neural interventions (i.e., submaximal exercise, baroreceptor reflex activation, pharmacological autonomic blockade, or bilateral cervical vagotomy).
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