Quantitative FDG-PET Analysis for Neuroimaging

Also, semiquantitative analysis of FDG-PET was conducted. The images have been anonymized before analysis. PMOD software (version 3.5, PMOD Technologies Limited, Zürich, Switzerland) was used for coregistration of all individual FDG-PET image volumes to an in-house FDG-PET template within the MNI space (Daerr et al., 2017 (link)). In analogy to the visual analysis, we measured the mean activity within bilateral parietal, bilateral temporal, and bilateral posterior cingulate cortex volumes of interest (VOIs) of the Hammers atlas (Hammers et al., 2003 (link)) and scaled the measured regional activities by a cerebellum reference region to generate standardized uptake value ratios (SUVr). Asymmetry was calculated by the Asymmetry-Index [AI = (left − right)/(left + right)*100] for hemispheres and subregions.

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Kreuzer A., Sauerbeck J., Scheifele M., Stockbauer A., Schönecker S., Prix C., Wlasich E., Loosli S.V., M. Kazmierczak P., Unterrainer M., Catak C., Janowitz D., Pogarell O., Palleis C., Perneczky R., Albert N.L., Bartenstein P., Danek A., Buerger K., Levin J., Zwergal A., Rominger A., Brendel M, & Beyer L. (2021). Detection Gap of Right-Asymmetric Neuronal Degeneration by CERAD Test Battery in Alzheimer’s Disease. Frontiers in Aging Neuroscience, 13, 611595.

Publication 2021

PMOD software (version 3.5,

Cerebellum Posterior cingulate cortex

Corresponding Organization : Ludwig-Maximilians-Universität München

Other organizations : German Center for Neurodegenerative Diseases, Imperial College London, Munich Cluster for Systems Neurology, University Hospital of Bern, University of Bern

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Mean activity within bilateral parietal, bilateral temporal, and bilateral posterior cingulate cortex volumes of interest (VOIs)
Standardized uptake value ratios (SUVr)
Asymmetry Index (AI) for hemispheres and subregions

control variables

FDG-PET image volumes were co-registered to an in-house FDG-PET template within the MNI space
Cerebellum was used as a reference region to generate standardized uptake value ratios (SUVr)

controls

Not mentioned
Not mentioned

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