We conducted a Genome Wide Association Study (GWAS) analysis among 458,577 UKB participants of European descent, identified from a combination of self-reported and genetic data. The details of the selection of the participants has been described elsewhere14 (link). These comprise 408,951 individuals from UKB genotyped at 825,927 variants with a custom Affymetrix UK Biobank Axiom Array chip and 49,626 individuals genotyped at 807,411 variants with a custom Affymetrix UK BiLEVE Axiom Array chip from the UK BiLEVE study, which is a subset of UKB. For our analyses, we used SNPs imputed centrally by UKB using the Haplotype Reference Consortium (HRC) panel.