MALT Lymphoma Eradication Therapy

Patients with gastric MALT lymphoma treated at our center between October 2006 and September 2020 and who received eradication therapy as frontline treatment were included in this study. Patients who received any other frontline treatment and lost follow-up cases were excluded. Treatment outcomes for all 137 cases were examined according to API2-MALT1 mutation and Hp infection status. Subsequently, in cases negative for both API2-MALT1 and Hp infection, the impact of the gene expression profile on response to eradication therapy was analyzed.

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Takigawa H., Yuge R., Miyamoto R., Otani R., Kadota H., Hiyama Y., Hayashi R., Urabe Y., Sentani K., Oue N., Kitadai Y., Oka S, & Tanaka S. (2023). Comprehensive Analysis of Gene Expression Profiling to Explore Predictive Markers for Eradication Therapy Efficacy against Helicobacter pylori-Negative Gastric MALT Lymphoma. Cancers, 15(4), 1206.

Publication 2023

Gastric Infection Malt lymphoma Malt1 Mutation Patients Therapy

Corresponding Organization : Hiroshima University

Other organizations : Hiroshima University Hospital, Prefectural University of Hiroshima

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Variable analysis

independent variables

API2-MALT1 mutation status
Helicobacter pylori infection status

dependent variables

Treatment outcomes

control variables

Patients with gastric MALT lymphoma treated at the center between October 2006 and September 2020
Patients who received eradication therapy as frontline treatment
Patients who did not receive any other frontline treatment
Patients who did not have lost follow-up cases

notes

The gene expression profile was analyzed as an independent variable in cases negative for both API2-MALT1 and Helicobacter pylori infection.

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