CMR examinations were conducted with a Philips 3-Tesla Achieva Tx whole body scanner (Philips Healthcare) equipped with a 32-element phased-array cardiac coil. The imaging protocol included an steady-state free-precession sequence to provide high-quality anatomic references, and assessment of LV mass and wall thickness; a T2W-STIR sequence to assess the extent of edema and IMH; a T2-gradient-spin-echo mapping sequence10 (link),16 (link); and a T1-weighted inversion recovery turbo field echo sequence to assess IS and MVO. CMR images were similarly analyzed using dedicated software (MR Extended Work Space 2.6, Philips Healthcare; and QMassMR 7.6, Medis) by 2 observers experienced in CMR analysis and blinded to group allocation.
Detailed information about MDCT and CMR imaging protocol and parameters, and imaging analysis, can be found in the online-only Data Supplement Methods.