Spectrophotometric Analysis of Naringin Encapsulation in PF68 Micelles

Methanol was used to disrupt the micellar structure to be then analyzed spectrophotometrically (ultraviolet/visible [UV/VIS] spectrophotometer; JASCO, Tokyo, Japan) for drug content at 281 nm vs plain micelles treated the same. The equations used for the estimation of LE% and EE% of naringin in PF68 micelles were as follows:43 (link)

LE % = \frac{Drug weight in the micelles}{Weight of drug and polymer added} \times 100 %

EE % = \frac{Drug weight in the micelles}{Weight of the drug added} \times 100 %

Further characterization of polymeric micelles with PF68 showing the highest EE% would be carried out.

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Mohamed E.A., Abu Hashim I.I., Yusif R.M., Shaaban A.A., El-Sheakh A.R., Hamed M.F, & Badria F.A. (2018). Polymeric micelles for potentiated antiulcer and anticancer activities of naringin. International Journal of Nanomedicine, 13, 1009-1027.

Publication 2018

ultraviolet/visible [UV/VIS] spectrophotometer

Drug Drug drug Methanol Micelles Naringin Polymeric

Corresponding Organization :

Other organizations : Mansoura University, Taibah University

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Variable analysis

independent variables

Methanol was used to disrupt the micellar structure

dependent variables

Drug content at 281 nm
Encapsulation Efficiency (EE%) of naringin in PF68 micelles
Loading Efficiency (LE%) of naringin in PF68 micelles

control variables

Plain micelles treated the same

controls

Positive control: Not specified
Negative control: Plain micelles treated the same

Annotations

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