Transgenic Mouse Models in Immunology

MRP8-Cre/iresGFP mice (B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J; Passegué et al., 2004 (link); Reber et al., 2017a (link)) were obtained from Irving Weissman (Stanford University, Stanford, CA) and Clifford Lowell (University of California, San Francisco, San Francisco, CA). Kit^W-sh/W-sh mice (B6.Cg-Kit^W-sh/HNihrJaeBsmGlliJ), Lys-Cre mice (B6.129P2-Lyz2^tm1(cre)Ifo/J), and Cd11c-Cre mice (B6.Cg-Tg(Itgax-cre)1-1Reiz/J) were obtained from The Jackson Laboratory. C57BL/6-Mcpt5-Cre⁺ mice (Dudeck et al., 2011 (link)) were provided by A. Roers. NLRP3^A350VneoR (B6.129-Nlrp3^tm1Hhf/J) and Nlrp3^L351PneoR mice (B6N.129-Nlrp3^tm2Hhf/J) have been described previously (Brydges et al., 2009 (link)). Mice were bred in the Institut Pasteur; University of California, San Diego; or Stanford University specific pathogen–free animal facilities. All animal care and experimentation were conducted in compliance with the guidelines of the National Institutes of Health and with the specific approval of the institutional animal care and use committees of Stanford University and the University of California, San Diego, and/or of the Committee for Ethics in Animal Experimentation (Institut Pasteur, Paris, France) registered under #C2EA-89.