Corilagin (purity ≥98%) was prepared at the Xiamen Overseas Chinese Subtropical Plant Introduction Garden (Xiamen, China) as previously described (21 (link)). Three HCC cell lines (SMMC-7721, Bel-l7402 and MHCC97-H) were used and all were obtained from the Cell Bank of the Chinese Academy of Sciences (Shanghai, China). RPMI-1640 medium and Dulbecco's modified Eagle's medium (DMEM) were obtained from Gibco (Thermo Fisher Scientific, Inc., Waltham, MA, USA). Bisbenzimide (Hoechst 33258), acridine orange (AO), JC-1, ethidium bromide (EB), methyl thiazolyl tetrazolium (MTT) and cisplatin (CDDP; purity ≥99.9%) were obtained from Sigma-Aldrich (Merck KGaA, Darmstadt, Germany). Annexin V-FITC/PI Apoptosis Detection kit was obtained from Roche (Mannheim, Germany). The antibodies against p53 (1:1,000; mouse mAb; cat. no. 48818), Bcl-2 (1:1,000; mouse mAb; cat. no. 15071), cytochrome c (1:1,000; rabbit mAb; cat. no. 11940), caspase-9 (1:1,000; mouse mAb; cat. no. 9508), caspase-8 (1:1,000; mouse mAb; cat. no. 9746), caspase-3 (1:1,000; rabbit mAb; cat. no. 9662), PARP (1:1,000; rabbit mAb; cat. no. 9746), surviving (1:1,000; mouse mAb, cat. no. 2802), Fas (1:1,000; mouse mAb; cat. no. 8023) and FasL (1:1,000; rabbit mAb; cat. no. 4273) were purchased from Cell Signaling Technology (Danvers, MA, USA).