Comprehensive Rabbit Hematological Analysis

Exsanguination and euthanasia were performed on all rabbits on the fifteenth day. Blood was drawn from the supraorbital vein into an EDTA-K2 blood collection tube for hematological testing. The results of the blood tests were recorded using the hematological analyzer. The blood sample was centrifuged at 3000 rpm for 10 min, and the biochemical characteristics of the serum were evaluated using a clinical chemistry analyzer. Rabbit necropsies were performed. Analytical balances were used to weigh the animal’s vital organs. Vital organs were maintained in a 10% formaldehyde solution for 72 h before histological analysis. Afterward, the tissue was cut into pieces and dehydrated using ethanol. Slides were prepared and stained using Hematoxylin and Eosin (H and E) and observed using an optical microscope.

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Farooq M., Usman F., Naseem M., Aati H.Y., Ahmad H., Manee S., Khalil R., Khan K.U., Qureshi M.I, & Umair M. (2023). Voriconazole Cyclodextrin Based Polymeric Nanobeads for Enhanced Solubility and Activity: In Vitro/In Vivo and Molecular Simulation Approach. Pharmaceutics, 15(2), 389.

Publication 2023

Animal organs Blood Blood tests Edta Eosin Ethanol Euthanasia Exsanguination Formaldehyde solution Hematoxylin Necropsies Optical microscope Rabbit Rabbits Serum Tissue Vein

Corresponding Organization : Islamia University of Bahawalpur

Other organizations : University of Balochistan, King Saud University, University of Central Punjab, Prince of Songkla University, Universidade de Vigo, Shenzhen Technology University

Top 5 similar protocols

Variable analysis

independent variables

Exsanguination and euthanasia performed on rabbits

dependent variables

Hematological test results
Biochemical characteristics of the serum
Weights of vital organs
Histological analysis of tissue samples

control variables

Blood collection method (supraorbital vein into EDTA-K2 blood collection tube)
Centrifugation conditions (3000 rpm for 10 min)
Formaldehyde fixation of tissue samples (10% formaldehyde solution for 72 h)
Tissue processing (dehydration using ethanol, slide preparation, Hematoxylin and Eosin staining)

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