From 2017, new annual enrollments are estimated as 1200 for kidney, 700 for liver, 100 for heart, and 30 for lung and pancreas transplantation, respectively. In kidney transplantation, the previous Retro-KOTRY collected the data of 4987 kidney recipients, and the effort is ongoing to collect the missing information (approximately 1200 kidney recipient’s data) from the end of the previous Retro-KOTRY enrollment and the launch of the prospective KOTRY-kidney (Figure 1). With the assumption of attaining the patient enrollment plan, Table 4 shows the minimum hazard ratios (HRs) detectable at a given prevalence level of risk factors by 2019, using exponential models based on the 20-year patient and graft survival for solid organ transplants from the Organ Procurement and Transplantation Network.19 The KOTRY-kidney cohort is estimated to detect a relative risk of 1.05 and 1.06 for graft survival and patient survival, respectively, with a 50% prevalent risk factor, at 5% alpha error and 20% beta error in an analysis using a Cox regression model (Table 4). Similarly, the KOTRY-liver, heart, lung, and pancreas cohorts will be able to detect HRs of 1.11, 1.32, 1.87, and 1.82, respectively, for graft survival.