Genetically Modified Mouse Models for Research

All animal work was approved by Duke University’s Institutional Animal Care and Use Committee. All mice were maintained in a barrier facility with 12-hour light/dark cycles. Mice were genotyped by PCR and both males and females were analyzed. TRE-Arhgef11^CA were generated in the lab as previously described [7 (link)]. Other animal strains used in this study were Villin-rtTA (Jackson Laboratories,[40 (link)]), VillinCre (Jackson Laboratories [41 (link)]), and Rosa-rtTA3 (Jackson Laboratories).

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Hinnant T., Ning W, & Lechler T. (2023). Compartment specific responses to contractility in the small intestinal epithelium. bioRxiv.

Publication Preprint 2023

Villin-rtTA VillinCre Rosa-rtTA3

Animal Females Institutional animal care and use committee Males Mice Rosa Strains Villin

Corresponding Organization : Yunnan University

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Variable analysis

independent variables

Genotype of mice (TRE-Arhgef11^CA, Villin-rtTA, VillinCre, Rosa-rtTA3)

dependent variables

Unspecified

control variables

Mouse sex (both males and females analyzed)
Housing conditions (12-hour light/dark cycles, maintained in a barrier facility)

controls

Positive controls: Not specified
Negative controls: Not specified

Annotations

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