Pancreatic Cancer Tissue Profiling

Two human pancreatic tissue cohorts were used in this study. The expression of UTX was analyzed in cohort #1 with 84 primary PDA, 84 adjacent pancreatic intraepithelial neoplasia (PanIN), and normal pancreatic tissue specimens (US Biomax). Correlation analysis of GATA6 and UTX protein expression was performed using cohort #2 with 60 PDA tissues. Immunohistochemical analyses of these specimens and xenografts were conducted with anti-GATA6 (R&D), anti-UTX (Bethyl Laboratories), and anti-Ki67 (Santa Cruz Biotechnology) antibodies as described previously.20 (link), 21 (link), 22 (link), 23 (link)

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Zhang H.Q., Kong F., Kong X., Jiang T., Ma M., Zheng S., Guo J, & Xie K. (2023). Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression. Genes & Diseases, 11(2), 921-934.

Publication 2023

anti-GATA6 anti-UTX anti-Ki67

Antibodies Human Pancreatic Pancreatic neoplasia Protein Tissues Xenografts

Corresponding Organization : Hainan Medical University

Other organizations : Jiangxi Provincial Cancer Hospital, Second Military Medical University, Changhai Hospital

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Variable analysis

independent variables

Presence of pancreatic cancer (primary PDA, adjacent PanIN, normal pancreatic tissue)

dependent variables

Expression of UTX protein
Expression of GATA6 protein

control variables

Specimen type (primary PDA, adjacent PanIN, normal pancreatic tissue)
Tissue samples (US Biomax and additional 60 PDA tissues)

controls

Positive control: Not explicitly mentioned.
Negative control: Not explicitly mentioned.

Annotations

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