Evaluating Tumor-Infiltrating Lymphocytes and Residual Cancer Burden

All specimens were pathologically reviewed. Evaluation of the core-needle
biopsy samples included assessments of stromal TILs and the nuclear and
histologic grades of each breast carcinoma sample. The levels of TILs are
expressed as percentages, as described by the International TIL Working
Group.^{17 (link)} The residual cancer burden (RCB) score,
Miller-Payne grade, residual tumor size, and TILs of the surgical specimens
were determined.^{18 (link),19 (link)} The tumor bed area in samples of patients who
achieved pCR group was marked and collected for high-throughput NGS.

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Shin J., Ham B., Seo J.H., Lee S.B., Park I.A., Gong G., Kim S.B, & Lee H.J. (2023). Immune repertoire and responses to neoadjuvant TCHP therapy in HER2-positive breast cancer. Therapeutic Advances in Medical Oncology, 15, 17588359231157654.

Publication 2023

Carcinoma of the breast Patients Residual cancer Residual tumor Surgical Tils Tumor

Corresponding Organization : Ulsan College

Other organizations : Kangbuk Samsung Hospital

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Variable analysis

independent variables

Stromal TILs
Nuclear grade
Histologic grade

dependent variables

Residual cancer burden (RCB) score
Miller-Payne grade
Residual tumor size
TILs of the surgical specimens

control variables

All specimens were pathologically reviewed

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