Dynamic PET/CT Image Analysis Protocol

Image processing of the PET/CT scans was performed by an experienced nuclear physician using PMOD 4.0 software (PMOD Technologies LLC, Zurich, Switzerland) (10 (link)). The 97 frames were merged into a single dynamic sequence to quantify tracer dynamics using co-registered dynamic PET and CT images. To account for the partial volume effect, this study involved delineating volumes of interest (VOIs), which were found to be 1–3 mm smaller in all dimensions than the actual region of interest observed in the images. The boundary definition of this VOI should be based on either CT or PET imaging, and we prioritized the smaller area as the more accurate representation of the region of interest. In this study, all organs were rendered to scale as previously specified, except for the skeletal bone, which was represented by the proximal femur. Time-activity curves (TACs) were then automatically generated using the kinetic modeling module of the PMOD software while taking into account the radioactive decay. The generated TACs were used to observe changes in uptake by the source organs.

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Xin M., Li L., Wang C., Shao H., Liu J, & Zhang C. (2023). Pilot study on 11C-CFT dynamic imaging using total-body PET/CT: biodistribution and radiation dosimetry in Parkinson's disease. Frontiers in Neurology, 14, 1153779.

Publication 2023

PMOD 4.0 software

Ct pet scans Femur Frames Kinetic Physician Radioactive decay Skeletal bone

Corresponding Organization :

Other organizations : Renji Hospital, Shanghai Jiao Tong University

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Variable analysis

independent variables

PMOD 4.0 software (PMOD Technologies LLC, Zurich, Switzerland)

dependent variables

Tracer dynamics quantified using co-registered dynamic PET and CT images
Uptake changes in source organs observed using time-activity curves (TACs)

control variables

Partial volume effect accounted for by delineating volumes of interest (VOIs) that were 1–3 mm smaller than the actual region of interest observed in the images
Boundary definition of VOIs based on either CT or PET imaging, with the smaller area prioritized as the more accurate representation of the region of interest
All organs rendered to scale as previously specified, except for the skeletal bone, which was represented by the proximal femur
Radioactive decay taken into account in the kinetic modeling module of the PMOD software when generating TACs

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