Endothelial Function in T2DM Patients

PREVAIL was a 20-week, open-label, parallel-arm trial wherein patients aged 30–80 years with T2DM of ≤ 7 years duration were randomized (1:1:1) to 8-weeks treatment with insulin glargine, glargine + thrice-daily lispro, or glargine + twice-daily exenatide, followed by 12-weeks washout. The study protocol and primary outcome have been described in detail previously [9 (link)]. The study was approved by the Mount Sinai Hospital Research Ethics Board and registered at ClinicalTrials.Gov (NCT02194595). All participants provided written informed consent. While the primary and metabolic outcomes have been reported recently [9 (link)], the current report presents the pre-specified ancillary outcome of endothelial function and associated vascular measures.

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Retnakaran R., Pu J., Ye C., Emery A., Kramer C.K, & Zinman B. (2023). The vascular function effects of adding exenatide or meal insulin to basal insulin therapy in early type 2 diabetes. Cardiovascular Diabetology, 22, 50.

Publication 2023

Endothelial Exenatide Glargine Lispro Patients Vascular

Corresponding Organization : Mount Sinai Hospital

Other organizations : University of Toronto

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Variable analysis

independent variables

Treatment with insulin glargine
Treatment with glargine + thrice-daily lispro
Treatment with glargine + twice-daily exenatide

dependent variables

Endothelial function
Associated vascular measures

control variables

Patients aged 30-80 years with T2DM of ≤ 7 years duration
12-weeks washout period

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