Clinical, laboratory, and chest imaging data obtained during COVID-19, other risk factors for severe COVID-19 (Rodrigues et al., 2020 (link); Zhang et al., 2020a (link), 2022a (link); Bennett et al., 2021 (link); Bourgeois et al., 2021 (link); Kooistra et al., 2021 (link); Navaratnam et al., 2021 (link); O’Driscoll et al., 2021 (link); Westblade et al., 2021 (link); Martin et al., 2022a (link); Schober et al., 2022 (link); Woodruff et al., 2022 (link)), and family history were collected for each patient in the survey. Concomitant infections were also recorded, when supported by clinical suspicion, positive cultures, and/or chest x-ray images. Adults with a body mass index (BMI) over 25 were considered to be overweight, and those with a BMI over 30 were considered to be obese. Children aged between 5 and 19 yr were considered to be obese if their BMI-for-age-and-sex was more than 2 SD above the WHO Growth Reference median. Children under 5 yr of age were considered to be obese if their weight-for-height was more than 3 SD above the WHO Child Growth Standard median (WHO, 2021 ).
COVID-19 severity was assessed according to the Human Genetic Effort clinical score (Asano et al., 2021 (link)). SARS-CoV-2 infection was classified as mild/non-confirmed pneumonia (for patients who were asymptomatic, presented upper respiratory tract disease with no signs of pneumonia on x ray or with respiratory symptoms not suggestive of a lower respiratory tract infection and therefore not requiring x ray), moderate (non-hypoxemic pneumonia, not requiring oxygen therapy), severe (hypoxemic pneumonia requiring therapy with oxygen <6 liters O2/min, without meeting the criteria for critical pneumonia) or critical (hypoxemic pneumonia requiring high-flow oxygen >6 liters O2/min, ventilatory support with or without intubation, or ECMO [extracorporeal membrane oxygenation]).
Laboratory values were recorded when available. Normal ranges of laboratory values were reported according to age and are expressed in standard units (Hollowell et al., 2005 (link); Mayo Clinic, 2022 ).
COVID-19 severity was assessed according to the Human Genetic Effort clinical score (Asano et al., 2021 (link)). SARS-CoV-2 infection was classified as mild/non-confirmed pneumonia (for patients who were asymptomatic, presented upper respiratory tract disease with no signs of pneumonia on x ray or with respiratory symptoms not suggestive of a lower respiratory tract infection and therefore not requiring x ray), moderate (non-hypoxemic pneumonia, not requiring oxygen therapy), severe (hypoxemic pneumonia requiring therapy with oxygen <6 liters O2/min, without meeting the criteria for critical pneumonia) or critical (hypoxemic pneumonia requiring high-flow oxygen >6 liters O2/min, ventilatory support with or without intubation, or ECMO [extracorporeal membrane oxygenation]).
Laboratory values were recorded when available. Normal ranges of laboratory values were reported according to age and are expressed in standard units (Hollowell et al., 2005 (link); Mayo Clinic, 2022 ).
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